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Tag: Social Sciences

Common Medications May Reduce Risk of Metastases after Colon and Rectal Cancer

Existing drugs to prevent anxiety, stress reactions and inflammation reduced the risk of the spread of cancer metastases after surgery to remove a colon tumor by tens of percent.

Although surgery to remove primary tumors is the mainstay of all cancer treatments, the risk of metastases after tumor removal is estimated at 35% among colon cancer patients, with higher risk in patients with more advance stages of the disease. However, a short, simple, and safe drug treatment developed at Tel Aviv University reduced the risk of the spread of cancer metastases after surgery to remove the primary tumor – according to the first clinical study of its kind conducted among 34 colon cancer patients operated on at Sheba Tel Hashomer Medical Center.

The research was led by Prof. Shamgar Ben-Eliyahu of TAU’s Sagol School of Neuroscience and School of Psychological Sciences at the Gershon H. Gordon Faculty of Social Sciences and Prof. Oded Zamora of TAU’s Sackler Faculty of Medicine, and its results were published in the European Journal of Surgical Oncology. At the same time, an overview of the theory and principles underlying the research was published in Nature Review Cancer.

“The stress during the waiting period for surgery, the stress and inflammation reactions that the body produces during the surgery itself and the physical recovery period, and finally the following anxiety of cancer recurring – all have an adverse effect on the body’s ability to fight metastatic processes,” explains Prof. Ben-Eliyahu. “These mental and physiological conditions create stress-inflammatory responses, which cause ample release of hormones from the prostaglandin and catecholamine families. These hormones suppress anti-metastatic immune activity, and thus encourage the development of metastases.”

“In addition, these hormones directly help the cancer cells that remain in the body even after surgery: due to exposure to these hormones, the cancerous tissue becomes more aggressive and metastatic. The good news is that we know how to treat both stress and inflammation using off-the-shelf medications.”

 

“This is a short, cheap drug treatment with no significant side effects. We deliberately sought the safest and cheapest drugs capable of lowering the body’s stress-inflammatory response to surgery, in order to save lives.” Prof. Shamgar Ben-Eliyahu

 

Significant and Encouraging Results

The researchers from Tel Aviv University gave 34 colon cancer patients two safe drugs that are available in every pharmacy: propranolol (Darlin), used to lower blood pressure and reduce anxiety, and etodolac (Etopan), used to prevent pain and inflammation.

Sixteen randomly chosen patients took the medication for 20 days – from five days before to two weeks after surgery at the Sheba Medical Center. The other 18 patients received placebo drugs (control group). Five years later, nine of the 18 patients who received the placebo (50%) developed cancer metastases, compared to two of the 16 patients who took Darlin and Etofen (12.5%).

“Although at five years after the operation, the statistical significance is clear, we need to conduct larger clinical studies,” says Prof. Ben-Eliyahu. “Our treatment reduced markers of metastasis in the tumor tissue and reduced the chances of cancer recurrence. This is a short, cheap drug treatment with no significant side effects. We deliberately sought the safest and cheapest drugs capable of lowering the body’s stress-inflammatory response to surgery, in order to save lives.”

“It sounds too good to be true, but similar results in breast cancer tissue were obtained in a study we conducted in 2017. Due to the small number of subjects in both studies, it is impossible to accurately estimate the magnitude of the beneficial effect, but the effects are statistically significant, meaning that they are not accidental.”

 

“We seek to save lives without financial gain, and we have received financial support from several Israeli and international sources, but these are insufficient for large clinical studies.” Prof. Shamgar  Ben-Eliyahu

 

Saving Lives Without Financial Gain

According to Prof. Ben-Eliyahu, part of the medical establishment distrusts the effects of stress-inflammatory reactions, particularly those resulting from psychological factors such as waiting for surgery or fear of the disease spreading. Another problem concerns the financing of clinical studies.

“One should bear in mind that the pharmaceutical companies have no financial incentive to support such studies. Our medicines are not patented; they are safe, cheap, and administered in a short treatment lasting just a few days. The drug companies look for patents on expensive drugs and prefer that the patient be dependent on the drug for the rest of their life.”

“Unfortunately, the major science foundations in Israel do not fund clinical research on drugs, assuming that the drug companies will fund them. We seek to save lives without financial gain, and we have received financial support from several Israeli and international sources, but these are insufficient for large clinical studies. I hope that funding will be found for a large-scale clinical study that we have now embarked on, with the intention of recruiting hundreds of colon and rectal cancer patients in Israel, because without such research – we will not be able to convince the medical establishment of the treatment’s effectiveness.”

Surprising the Pope with The Artwork ‘Jesus from the Soil of the Holy Land’

Prof. Dina Porat: “The Pope was moved by the gesture. He thanked me wholeheartedly and said that it was a very special gift.”

Prof. Dina Porat from Tel Aviv University recently surprised Pope Francis when she handed him the artwork ‘Jesus from the Soil of the Holy Land’ while in Rome. The Pope thanked Prof. Porat wholeheartedly for the “very special gift”.

 

“Nilly sent me a photo of the unusual composition and asked, half-jokingly, if perhaps I could meet the Pope and bring him a very special gift from the soil of the Holy Land.” Prof. Dina Porat.

 

From the fields of Israel to the Vatican

‘Jesus from the Soil of the Holy Land’ was conceived, almost accidentally, by artist Nilly Shachor from Sde Warburg, a moshav in central Israel.

One day, as she was walking in the fields near her home, Shachor tripped and fell. When she got up, she saw that she had tripped on some branches that lay on the ground in an unusual formation, reminding her of Jesus Christ: two branches spreading sideways like human arms, a disheveled head, and long thin legs. Even a wreath was in place on Jesus’ head.

Shachor took the branches home, cleaned them, and embellished the wreath with some more twigs and thorns.  

 

The artwork ‘Jesus from the Soil of the Holy Land’

Shachor called her friend, Prof. Dina Porat from Tel Aviv University’s Chaim Rosenberg School of Jewish Studies and Archaeology at The Lester and Sally Entin Faculty of Humanities, who was planning to attend an international conference on antisemitism in Rome a few days later.

“Nilly sent me a photo of the unusual composition and asked, half-jokingly, if perhaps I could meet the Pope and bring him a very special gift from the soil of the Holy Land,” recalls Prof. Porat.

 

“It was a very meaningful experience for me, and I hope that ‘Jesus from the soil of the Holy Land’ is now displayed on a wall somewhere in the Vatican.” Prof. Dina Porat

 

Challenge Accepted

Accepting the challenge, Prof. Porat framed the photo in gold and called an old friend, Father Norbert Hofmann, Secretary of the Vatican’s Commission for Religious Relations with the Jews, who immediately agreed to help.

“When I arrived in Rome, my friend Norbert said that the next day, like every Wednesday, the Pope would hold the General Audience in which he greets visitors, and that it had been arranged for us to sit in the VIP section, right next to the stage,” recounts Prof. Porat.

“It was a very exciting event. Thousands of people gathered in Saint Peter’s Square, the Vatican’s large plaza, sang songs and merrily waved their flags. The Pope approached and shook people’s hands. When he approached me, I offered him the gift. He was moved and asked his attendants to safeguard the artwork. It was a very meaningful experience for me, and I hope that ‘Jesus from the soil of the Holy Land’ is now displayed on a wall somewhere in the Vatican.”

The Bible – Fact or Fiction?

Researchers confirm invasions of biblical Israel using geomagnetic fields.

A joint study by TAU and the Hebrew University, involving 20 researchers from different countries and disciplines, has accurately dated 21 destruction layers at 17 archaeological sites in Israel by reconstructing the direction and/or intensity of the earth’s magnetic field recorded in burnt remnants. The new data verify the Biblical accounts of the Egyptian, Aramean, Assyrian, and Babylonian military campaigns against the Kingdoms of Israel and Judah.

Findings indicate, for example, that the army of Hazael, King of Aram-Damascus, was responsible for the destruction of several cities – Tel Rehov, Tel Zayit, and Horvat Tevet, in addition to Gath of the Philistines, whose destruction is noted in the Hebrew Bible. At the same time, the study refutes the prevailing theory that Hazael was the conqueror who destroyed Tel Beth-Shean.

Other geomagnetic findings reveal that the cities in the Negev were destroyed by the Edomites, who took advantage of the destruction of Jerusalem and the Kingdom of Judah by the Babylonians.

The groundbreaking interdisciplinary study was published in PNAS (Proceedings of the National Academy of Sciences of the USA) and is based on the doctoral thesis of Yoav Vaknin, supervised by Prof. Erez Ben-Yosef and Prof. Oded Lipschits of TAU’s Nadler Institute of Archaeology and Prof. Ron Shaar from the Institute of Earth Sciences at the Hebrew University.

WATCH: Yoav Vaknin from TAU’s Sonia and Marco Nadler Institute of Archaeology explains about the research

 

Reliable Tool for Archaeological Dating

The researchers explain that geophysicists, attempting to understand the mechanism of earth’s magnetic field, track changes in this field throughout history. To this end, they use archaeological findings containing magnetic minerals which, when heated or burned, record the magnetic field at the time of the fire.

Thus, in a 2020 study, researchers reconstructed the magnetic field as it was on the 9th of the month of Av, 586 BCE, the Hebrew date of the destruction of the First Temple and the City of Jerusalem by Nebuchadnezzar and his Babylonian army.

Now, using archaeological findings unearthed over several decades at 17 sites throughout Israel, alongside historical information from ancient inscriptions and Biblical accounts, the researchers were able to reconstruct the magnetic fields recorded in 21 destruction layers. They used the data to develop a reliable new scientific tool for archaeological dating.

Yoav Vaknin explains: “Based on the similarity or difference in intensity and direction of the magnetic field, we can either corroborate or disprove hypotheses claiming that specific sites were burned during the same military campaign. Moreover, we have constructed a variation curve of field intensity over time which can serve as a scientific dating tool, similar to the radiocarbon dating method.”

Yoav Vaknin measuring at the site (Photo: Shai Halevi, Israel Antiquities Authority)

One example given by the researchers is the destruction of Gath of the Philistines (identified today as Tel Tzafit in the Judean foothills) by Hazael, King of Aram-Damascus. Various dating methods have placed this event at around 830 BCE but were unable to verify that Hazael was also responsible for the destruction of Tel Rehov, Tel Zayit and Horvat Tevet.

The new study, identifying full statistical synchronization between the magnetic fields recorded at all these four sites at the time of destruction, now makes a very strong case for their destruction having taken place during the same campaign.

A destruction level at Tel Beth-Shean, on the other hand, recording a totally different magnetic field, refutes the prevailing hypothesis that it too was destroyed by Hazael. Instead, the magnetic data from Beth-Shean indicate that this city, along with two other sites in northern Israel, was probably destroyed 70-100 years earlier, a date which could correspond with the military campaign of the Egyptian Pharaoh Shoshenq.

Shoshenq’s campaign is described in the Hebrew Bible and in an inscription on a wall of the Temple of Amun in Karnak, Egypt, which mentions Beth-Shean as one of his conquests.

 

“While Jerusalem and frontier cities in the Judean foothills ceased to exist, other towns in the Negev, the southern Judean Mountains and the southern Judean foothills remained almost unaffected. Now, the magnetic results support this hypothesis, indicating that the Babylonians were not solely responsible for Judah’s ultimate demise.” Prof. Erez Ben Yosef

 

Judah’s Ultimate Demise

One of the most interesting findings revealed by the new dating method has to do with the end of the Kingdom of Judah. Prof. Erez Ben Yosef: “The last days of the Kingdom of Judah are widely debated. Some researchers, relying on archaeological evidence, argue that Judah was not completely destroyed by the Babylonians. While Jerusalem and frontier cities in the Judean foothills ceased to exist, other towns in the Negev, the southern Judean Mountains and the southern Judean foothills remained almost unaffected. Now, the magnetic results support this hypothesis, indicating that the Babylonians were not solely responsible for Judah’s ultimate demise.”

“Several decades after they had destroyed Jerusalem and the First Temple, sites in the Negev, which had survived the Babylonian campaign, were destroyed – probably by the Edomites who took advantage of the fall of Jerusalem. This betrayal and participation in the destruction of the surviving cities may explain why the Hebrew Bible expresses so much hatred for the Edomites – for example, in the prophecy of Obadiah.”   

Prof. Oded Lipschits adds that “the new dating tool is unique because it is based on geomagnetic data from sites, whose exact destruction dates are known from historical sources. By combining precise historical information with advanced, comprehensive archaeological research, we were able to base the magnetic method on reliably anchored chronology.”

 

Burnt mud stones

 

“Until recently scientists believed that [the magnetic field] remains quite stable for decades, but archaeomagnetic research has contradicted this assumption by revealing some extreme and unpredictable changes in antiquity.” Prof. Ron Shaar

 

Taking Advantage of an Unstable Geomagnetic Field

Prof. Ron Shaar, who led the geophysical aspects of the study, as well as the development of the geomagnetic dating method, explains: “Earth’s magnetic field is critical to our existence. Most people don’t realize that without it there could be no life on earth – since it shields us from cosmic radiation and the solar wind. In addition, both humans and animals use it to navigate.”

“The geomagnetic field is generated by earth’s outer core, at a depth of 2,900 km, by currents of liquid iron. Due to the chaotic motion of this iron, the magnetic field changes over time. Until recently scientists believed that it remains quite stable for decades, but archaeomagnetic research has contradicted this assumption by revealing some extreme and unpredictable changes in antiquity.”

“Our location here in Israel is uniquely conducive to archaeomagnetic research, due to an abundance of well-dated archaeological findings. Over the past decade we have reconstructed magnetic fields recorded by hundreds of archaeological items. By combining this dataset with the data from Yoav’s investigation of historical destruction layers, we were able to form a continuous variation curve showing rapid, sharp changes in the geomagnetic field. This is wonderful news, both for archaeologists, who can now use geomagnetic data to determine the age of ancient materials, and for geophysicists studying the earth’s core.”

A separate paper, presenting the scientific principles of the novel archaeomagnetic dating method, is in preparation.

Want Success in Business? Have a Diverse Workforce

Diversity in gender and ethnicity among employees can lead to over 50% improvement in company decision-making.

Gender and ethnic diversity in the workplace are not just a matter of morality or political correctness, according to Prof. Thalma Lobel of Tel Aviv University’s School of Psychological Sciences. Lobel explains that diversity, in fact, contributes to the success of companies and organizations worldwide.  
“When you bring people with different opinions into the room, the decision-making process becomes more complex, and the participants take more information into account. The more perspectives and points of view that are heard, the greater the chances of reaching a better solution.”
 

More Points of View

In her study, Lobel presents a wealth of empirical evidence that gender and ethnic diversity improves the performance of companies and organizations – to the point of bringing about a 58% improvement in decision-making. She mentions as an example a 2008 report, which she says, “found that among the companies included in the Fortune 500 list, those whose board of directors included more women achieved better financial results.” In another example, researchers from the Credit Suisse Research Institute surveyed 2,360 companies and found that the ones whose board of directors included at least one woman performed better than those whose board consisted of only men. A McKinsey report examined the impact of gender and multinational diversity on companies’ financial performance. The researchers looked at the composition of the boards of directors of 180 companies in France, Germany, Great Britain and the United States from 2008 to 2010, and the results were clear: the financial success of the companies that were characterized by diversity were significantly higher than those that were less diverse.” According to Prof. Lobel, these and other studies clearly demonstrate that diversity offers significant benefits to companies and improves their functioning, since people from different backgrounds bring with them a variety of perspectives, points of view, and types of knowledge, and this variety contributes to innovation and creativity: “When you bring people with different opinions into the room, the decision-making process becomes more complex and the participants take more information into account. The more perspectives and points of view that are heard, the greater the chances of reaching a better solution.”   Prof. Thalma Lobel  
“This was a surprising finding which may have far-reaching implications: the mere presence of the minorities changed the trend of decision-making.”
 

Diversity – Louder than Words

Diversity in the workplace, in fact, improves performance even if the diverse perspectives are not heard at all. “Researchers examined the effect of diversity in racial origin on decision-making and the performance of traders in the capital market,” says Prof. Lobel. “They invited people with a financial background to participate in the study, and trained them to calculate the intrinsic value of stocks. The participants were then divided into groups with either a homogenous or diverse make-up. The diverse groups included at least one person of a different origin than the other participants. The researchers conducted their study in two markets – North America and Southeast Asia. “In North America, the homogenous group included only white traders, while the diverse group included one trader of African-American origin and one of Latino origin. In Asia, the homogenous group was composed of only Chinese traders, and the diverse group also included traders from Malaysia and India. The results were astonishing: the members of the diverse groups demonstrated a significantly higher level of accuracy in stock pricing than the homogeneous groups. Their ability to quote a price that reflected the true value of the assets was 58% higher. “The members of the homogeneous groups tended to pay unreasonable and exorbitant prices, which were further from the true value of the stocks than those quoted by the diverse groups. In other words, the chances of a dangerous bubble forming were higher when the trading was carried out by a homogenous group, and lower when the traders belonged to different ethnic groups. This was a surprising finding which may have far-reaching implications: the mere presence of the minorities changed the trend of decision-making.”  
“When you form a team, task force or committee, try to include as many people as possible from a variety of ethnic groups, genders, and backgrounds.”
 

Get an Outsider’s Opinion

In her book, Whatever Works, published in the United States in 2020, Prof. Lobel presents findings that extend far beyond the world of work and business: A study conducted by Prof. Richard Freeman and his doctoral student Wei Huang of Harvard University compared 2.5M articles published in scientific journals, and found that articles whose authors came from diverse ethnic backgrounds garnered more mentions and citations in the scientific literature. “Many studies show that working in a diverse team contributes to better decision-making,” Prof. Lobel concludes. “In light of this, you should take a look around the next time you’re working on a joint project. Are all your team members of the same gender and ethnic group as you? If the answer is yes, you should carefully consider all your options and avoid rushing to make any decisions. You will likely benefit from getting an outsider’s opinion. When you form a team, task force or committee, try to include as many people as possible from a variety of ethnic groups, genders, and backgrounds.”

Our Ancestors Irreparably Damaged the Timna Valley Environment 3000 Years Ago

Their activities destroyed local vegetation for the copper industry.

Humans destroying ecosystems apparently dates as far back as to biblical times: Researchers from Tel Aviv University collected samples of charcoal used as fuel for metallurgical furnaces in the Timna Valley, located in Israel’s southern desert region, during the 11th-9th centuries BCE and examined them under a microscope. They found that the charcoal fuels used changed over time. The earlier samples contained mainly local white broom and acacia thorn trees, excellent fuel available nearby, but the quality of the firewood had deteriorated over time, with later samples consisting of low-quality wood fuel and timber imported from afar. The researchers: “Our findings indicate that the ancient copper industry at Timna was not managed in a sustainable manner, with overexploitation of local vegetation eventually leading to the disappearance of both the plants and the industry. Copper production was not renewed in this region until about a thousand years later, and the local environment has not recovered fully to this day.”  
“We can only assume that [King] David took an interest in this remote desert region because of its copper – an important and valuable metal at the time, used for making bronze among other purposes.”
 

Why Burn so Many Trees?

The study was conducted by PhD student Mark Cavanagh, Prof. Erez Ben-Yosef, and Dr. Dafna Langgut, head of the Laboratory of Archaeobotany and Ancient Environments, all from TAU’s Jacob M. Alkow Department of Archaeology and Ancient Near Eastern Cultures, and Dr. Langgut is also affiliated with the Steinhardt Museum of Natural History. The study was published in the prestigious journal Scientific Reports from the Nature portfolio. “Many findings in the Timna Valley indicate that a vast copper industry flourished here for a period of about 250 years, between the 11th and 9th centuries BCE, with thousands of mining sites, and about 10 processing sites that used furnaces to extricate copper from the ore,” says Prof. Erez Ben-Yosef, director of the archaeological excavations in the Timna Valley. “This impressive operation is known to the public as ‘King Solomon’s Mines’, and today we know that copper production peaked here at about the time of Kings David and Solomon.” “The Bible never mentions the mines as such, but it does tell us that David conquered the area of Timna, known at the time as Edom, placing garrisons throughout the land, so that the Edomites became his subjects; and that his son Solomon used huge quantities of copper for building the Temple in Jerusalem. We can only assume that David took an interest in this remote desert region because of its copper – an important and valuable metal at the time, used for making bronze among other purposes. The Timna copper industry was run by the local Edomites, who specialized in this profession, and copper from Timna was exported to distant lands, including Egypt, Lebanon, and even Greece. This study shows, however, that the industry was not sustainable, a fact that may fit in well with occupation by a foreign power, perhaps ruled from Jerusalem.” Investigating a pile of industrial waste mixed with charcoal on Slaves’ Hill, Timna Valley (photo: Erez Ben-Yosef and the Central Timna Valley Project) The researchers explain that Timna’s copper industry was highly advanced for its time, and that the metalsmiths who processed the copper were skilled and well-respected individuals. The copper was extracted from the ore via smelting in earthenware furnaces at a temperature of 1,200 degrees Celsius. The entire process took about eight hours, after which the furnace was smashed, and the copper retrieved from its base. The wood charcoal required to attain the high temperature was manufactured beforehand at special sites, by slow combustion of trees and bushes cut down for this purpose.

Where did the Firewood Come From?

Ever since the copper industry at Timna was first discovered, about 200 years ago, researchers have repeatedly asked what fuel was used to heat the smelting furnaces. Since vegetation is very sparse in this desert area, where did the firewood come from? “In order to finally solve this mystery, we collected samples of charcoal from the smelting sites and examined them in the lab,” says Mark Cavanagh. The charcoal samples, well-preserved thanks to the dry desert climate, were taken from mounds of industrial waste at two large production sites in the Timna Valley and brought to the archaeobotanical laboratory at TAU. “At the lab we examine plant remains discovered at archeological excavations,” explains Dr. Dafna Langgut. “In the present study we examined more than 1,000 charcoal samples under an electronic microscope. The anatomic structure of the original wood is preserved in the charcoal, and under the microscope the species can be identified. The samples were dated according to the layer of the waste mound in which they had been found, and some were also sent out for carbon-14 dating.”  
“The production site called the ‘Slaves’ Hill’ (…) burned as many as 400 acacias and 1,800 brooms every year. As these resources dwindled, the industry looked for other solutions, as evidenced by the changing composition of the charcoal.”
  Excavating Slaves’ Hill (photo: Hai Ashkenazi, courtesy of the Central Timna Valley Project) Mark Cavanagh describes the findings: “We found significant changes in the composition of the charcoal as time went on. Charcoal from the bottom layer of the mounds, dated to the 11th century BCE, mostly contained two plants known to be excellent burning materials: 40% acacia thorn trees, and 40% local white broom, including broom roots. The ‘burning coals of the broom tree’ are even mentioned in the Bible as excellent firewood (Psalm 120, 4). About 100 years later, around the middle of the 10th century BCE, we saw a change in the makeup of the charcoal. The industry had begun to use fuel of a lower quality, such as various desert bushes and palm trees. In this latter stage, other trees were imported from far away, such as junipers from the Edomite plateau in present-day Jordan, covering distances of up to 100 km from Timna, and terebinth, also transported from dozens of kilometers away.”

Lasting Damage

The researchers claim that the gradual change in the contents of the charcoal resulted from overexploitation that had destroyed the natural resources – in this case high-quality firewood, the acacia and white broom. Prof. Ben-Yosef: “Based on the amount of industrial waste found at the processing sites we can calculate the quantity of woody plants required for producing copper. For example, the production site called the ‘Slaves’ Hill’, which was only one of several sites operating simultaneously, burned as many as 400 acacias and 1,800 brooms every year. As these resources dwindled, the industry looked for other solutions, as evidenced by the changing composition of the charcoal. However, transporting woody plants from afar did not prove cost-effective for the long run, and eventually, during the 9th century BCE, all production sites were shut down. The copper industry in the Timna Valley was renewed only 1,000 later, by the Nabateans.” Dr. Langgut concludes: “Our study indicates that 3,000 years ago humans caused severe environmental damage in the Timna Valley, which affects the area to this day. The damage was caused through overexploitation, especially of the acacia and white broom, which, as key species in the ecosystem of the Southern Arava, had supported many other species, stored water, and stabilized the soil. Their disappearance generated a domino effect of environmental damage, irreparably harming the entire area. Three thousand years later, the local environment still hasn’t recovered from the crisis. Some species, like the white broom, once prevalent in the Timna Valley, are now very rare, and others have disappeared forever.” Tel Aviv University’s Dr. Dafna Langgut and Prof. Erez Ben-Yosef

World’s Earliest Evidence of Opium Use

Opium residue was found in Israel, dating back to the 14th century BC. Researchers believe Canaanites used the psychoactive drug as offering for the dead.

A new study by the Israel Antiquities Authority, Tel Aviv University and The Weizmann Institute of Science has revealed the earliest known evidence of the use of the hallucinogenic drug opium, and psychoactive drugs in general, in the world. The opium residue was found in ceramic vessels discovered at Tel Yehud in Israel, in an excavation conducted by Eriola Jakoel on behalf of the Antiquities Authority. The vessels that contained the opium date back to the 14th century BC, and were found in Canaanite graves, apparently having been used in local burial rituals. This exciting discovery confirms historical writings and archeological hypotheses according to which opium and its trade played a central role in the cultures of the Near East. The research was conducted as part of Vanessa Linares’s doctoral thesis, under the guidance of Prof. Oded Lipschits and Prof. Yuval Gadot of Tel Aviv University’s Department of Archeology and Prof. Ronny Neumann of the Weizmann Institute, in collaboration with Eriola Jakoel and Dr. Ron Be’eri of the Israel Antiquities Authority. The study was published in the journal Archaeometry.  
“Because the vessels are similar in shape to the poppy flower when it is closed and upside down, the hypothesis arose already in the 19th century that they were used as ritual vessels for the drug.”
 

Thoughtful Send-off

In 2012, the Antiquities Authority conducted a salvage excavation at the Tel Yehud site, prior to the construction of residences there. Several Canaanite graves from the Late Bronze Age were found in the excavation, and next to them burial offerings – vessels intended to accompany the dead into the afterlife. Among the pottery, a large group of vessels made in Cyprus and referred to in the study as “Base-Ring juglets,” stood out. Because the vessels are similar in shape to the poppy flower when it is closed and upside down, the hypothesis arose already in the 19th century that they were used as ritual vessels for the drug. Now, an organic residue analysis has revealed opium residue in eight vessels, some local and some made in Cyprus. This is the first time that opium has been found in pottery in general, and in Base-Ring vessels in particular. It is also the earliest known evidence of the use of hallucinogens in the world.   Vessels intended to accompany the dead into the afterlife. These Cypriot jugs and juglets were laid on the deceased. Remains of opium were found in several of the vessels (photo: Assaf Peretz, Israel Antiquities Authority)  
“It may be that during these ceremonies, conducted by family members or by a priest on their behalf, participants attempted to raise the spirits of their dead relatives in order to express a request, and would enter an ecstatic state by using opium.”
 

Raising Spirits

“In the excavations conducted at Tel Yehud to date, hundreds of Canaanite graves from the 18th to the 13th centuries BC have been unearthed,” shares Dr. Ron Be’eri of the Israel Antiquities Authority. “Most of the bodies buried were those of adults, of both sexes. The pottery vessels which had been placed within the graves were used for ceremonial meals, rites and rituals performed by the living for their deceased family members.” Beeri explains that the dead were honored with foods and drinks that were either placed in the vessels or consumed during a feast that took place over the grave, at which the deceased was, in fact, considered a participant. It may be that during these ceremonies, conducted by family members or by a priest on their behalf, participants attempted to raise the spirits of their dead relatives to express a request, and would enter an ecstatic state by using opium. Alternatively, he says, the opium, which was placed next to the body, may have been intended to help the spirit of the deceased rise from the grave in preparation for the meeting with their relatives in the next life.  
“Canaanites attached great importance to ‘satisfying the needs of the dead’ through ritual ceremonies performed for them by the living, and believed that in return, the spirits would ensure the health and safety of their living relatives”
 

Highly Valued Drug

Vanessa Linares of Tel Aviv University explains: “This is the only psychoactive drug that has been found in the Levant in the Late Bronze Age. In 2020, researchers discovered cannabis residue on an altar in Tel Arad, but this dated back the Iron Age, hundreds of years after the opium in Tel Yehud. Because the opium was found at a burial site, it offers us a rare glimpse into the burial customs of the ancient world. Of course, we do not know what the opium’s role was in the ceremony – whether the Canaanites in Yehud believed that the dead would need opium in the afterlife, or whether it was the priests who consumed the drug for the purposes of the ceremony.” “Moreover, the discovery sheds light on the opium trade in general. One must remember that opium is produced from poppies, which grew in Asia Minor – that is, in the territory of current-day Turkey – whereas the pottery in which we identified the opium were made in Cyprus. In other words, the opium was brought to Yehud from Turkey, through Cyprus; this of course indicates the importance that was attributed to the drug.” Dr. Ron Be’eri of the Antiquities Authority adds, “Until now, no written sources have been discovered that describe the exact use of narcotics in burial ceremonies, so we can only speculate what was done with opium. From documents that were discovered in the Ancient Near East, it appears that the Canaanites attached great importance to ‘satisfying the needs of the dead’ through ritual ceremonies performed for them by the living, and believed that in return, the spirits would ensure the health and safety of their living relatives.” According to Eli Eskosido, director of the Israel Antiquities Authority, “New scientific capabilities have opened a window for us to fascinating information and have provided us with answers to questions that we never would have dreamed of finding in the past. One can only imagine what other information we will be able to extract from the underground discoveries that will emerge in the future.” Featured image: Vanessa Linares from Tel Aviv University’s Department of Archeology

Facebook Proven to Negatively Impact Mental Health

New study first to establish causal link between use of the platform and reported worsening in anxiety and depression among college students.

While many studies have found a correlation between the use of social media and various symptoms related to mental health, so far, it has been challenging to ascertain whether social media was actually the cause of poor mental health. By applying a novel research method, researchers have now succeeded in establishing such a causality: A study led by researchers from Tel Aviv University, MIT Sloan School of Management and Bocconi University reveals new findings about the negative impact of Facebook on the mental health of American college students.

 

The study was led by Dr. Roee Levy of the Berglas School of Economics at Tel Aviv University, Prof. Alexey Makarin of MIT Sloan School of Management, and Prof. Luca Braghieri of Bocconi University. The paper is forthcoming in the scientific journal American Economic Review, and was awarded a prize at the 2022 Economic Society European Meeting (ESEM).

 

“Over the last fifteen years, the mental health trends of adolescents and young adults in the United States have worsened considerably,” says Prof. Braghieri. “Since such worsening in trends coincided with the rise of social media, it seemed plausible to speculate that the two phenomena might be related.” 

 

The study was based on data that dates back to the 2004 advent of Facebook at Harvard University, before it took the internet by storm. Facebook was initially accessible only to Harvard students who had a Harvard email address. Quickly spreading to other colleges in and outside the US, the network was made available to the general public in the US and beyond in September 2006. The researchers were able to analyze the impact of social media use by comparing colleges that had access to the platform to colleges that did not. The findings show a rise in the number of students reporting severe depression and anxiety (7% and 20% respectively). 

 

“We hypothesized that unfavorable social comparisons could explain the effects we found, and that students more susceptible to such comparisons were more likely to suffer negative effects.”

 

 

Here Comes Trouble

The study combined information from two different datasets: the specific dates on which Facebook was introduced at 775 American colleges, and the National College Health Assessment (NCHA), a survey conducted periodically at American colleges.

 

The researchers built an index based on 15 relevant questions in the NCHA, in which students were asked about their mental health in the past year. They found a statistically significant worsening in mental health symptoms, especially depression and anxiety, after the arrival of Facebook: 

  • 7% increase in number of students who reported having suffering, at least once during the preceding year, depression so severe that it was difficult for them to function 
  • 20% increase in number of students who reported anxiety disorders 
  • 2% increase in number of students expected to experience moderate to severe depression 
  • 3% increase in number of students experienced impairment to their academic performance due to depression or anxiety 
     

Dr. Roee Levy (Photo: Oren Sarig)

 

 

Social Media vs. Social Circumstances

TAU’s Dr. Levy notes, “When studying the potential mechanisms, we hypothesized that unfavorable social comparisons could explain the effects we found, and that students more susceptible to such comparisons were more likely to suffer negative effects.”

 

“More students believed that others consumed more alcohol, even though alcohol consumption had not changed significantly.”  

 

In other words, the methodology also considered any differences in mental health over time or across colleges that were not related to Facebook. This approach enabled conditions similar to those of a ‘natural experiment,’ which would be impossible today now that billions of people around the world use many different social networks.

 

To test this interpretation, the team investigated more data from the NCHA. They found, for example, a greater negative impact on the mental health of students who lived off-campus and were consequently less involved in social activities, and a greater negative impact on students with credit card debts who saw their supposedly wealthier peers on the network. 

 

“We also found evidence that Facebook had changed students’ beliefs about their peers,” adds Levy. “More students believed that others consumed more alcohol, even though alcohol consumption had not changed significantly.”  

Can Music Help Prevent Severe Cognitive Decline?

TAU researchers developed musical tests to detect mental deterioration in old age.

Modern technology contributes to increased longevity and thus to the growth of the elderly population. It is therefore important to take steps to ensure their quality of life, including inventing tools for accessible and quick diagnosis of age-related conditions. While preventative tests are commonly accepted for a variety of physiological problems such as diabetes, high blood pressure or breast cancer, no method has yet been developed to enable routine, accessible monitoring of the brain for cognitive issues.

 

Researchers at Tel Aviv University have developed a method that employs musical tests and a portable instrument for measuring brain activity to detect cognitive decline in old age. The method entails measuring 15 minutes of electrical activity in the subject’s brain while he or she performs simple musical tasks and can be easily implemented by any staff member in any clinic, without requiring special training. The researchers believe the method could pave the way towards early detection of cognitive decline when treatment and prevention of severe decline are possible, improving the quality of life of millions around the world

 

Many Powers of Music

The study was led at Tel Aviv University by PhD student Neta Maimon from the School of Psychological Sciences and the Buchmann-Mehta School of Music, and Lior Molcho from Neurosteer Ltd, headed by Prof. Nathan Intrator from the Blavatnik School of Computer Science and the Sagol School of Neuroscience. Other participants included: Adi Sasson, Sarit Rabinowitz, and Noa Regev-Plotnick from the Dorot-Netanya Geriatric Medical Center. The article was published in the journal Frontiers in Aging Neuroscience.

 

As part of the study, the researchers developed a groundbreaking method combining a portable device for the measurement and innovative analysis of electroencephalography (EEG), developed by Neurosteer, and a short musical test of about 12-15 minutes, developed by Maimon.

 

“We have actually succeeded in illustrating that music is indeed an effective tool for measuring brain activity.”

 

Maimon, who specializes in musical cognition, explains that music has great influence on different centers in the brain. On the one hand, music is known to be a quick mood stimulant, particularly of positive emotion. On the other hand, in different situations, music can be cognitively challenging, activating the frontal parts of the brain, especially if we try to concentrate on different aspects of the music, and at the same time perform a particular task. According to Maimon, if we combine these two capabilities, we can create cognitive tests that are quite complex, yet also pleasant and easy to perform.

 

Neta Maimon specializes in musical cognition

 

Furthermore, music that is positive and reasonably rhythmic will enhance concentration and performance of the task. Thus, for example, the famous “Mozart effect,” whereby subjects perform better on intelligence tests after listening to Mozart’s music, has nothing to do with Mozart’s music, but rather the fact that music creates a positive mood and stimulates us to a state that is optimal for performing intelligence and creativity tests.

 

Accordingly, the researchers hypothesized that with musical tools, it would also be possible to challenge the subjects to an extent that would enable testing of the brain’s frontal activity as well as raising their spirits, thus enhancing their performance on the test while the overall experience is pleasant.

 

Enabling Early Detection of Cognitive Decline

The study included an experiment testing 50 elderly people hospitalized at the Dorot-Netanya Geriatric Medical Center. “Anyone hospitalized at Dorot, or any other geriatric rehabilitation institution, undergoes a standard test called ‘mini-mental,’ designed to evaluate their cognitive condition as a routine part of the intake process,” explains Maimon.

 

During the test, the subject is connected to the portable EEG device by means of an adhesive band with three electrodes attached to the forehead. The test includes a variety of tasks, including enumerating the days of the week or months of the year backwards. The subject performs a series of musical-cognitive tasks according to audible instructions given automatically through earphones. Short melodies are played by different instruments, and the subjects are instructed to perform various tasks on them at varying levels of difficulty. For example, pressing a button each time any melody is played or pressing it only when the violin plays. In addition, the test includes several minutes of musically guided meditation designed to bring the brain to a resting state, as this state is known to indicate cerebral functioning in various situations. Up to 30 points can be accrued, a high score indicating normal cognition.

 

“Our method enables the monitoring of cognitive capability and detection of cognitive decline already in the early stages, all by simple and accessible means.”

 

“The participants scored 18-30 on the mini-mental test, indicating various levels of cognitive functioning,” explains Maimon. “The EEG device registered the electrical activity in the brain during the activity, and the results were analyzed using machine learning technology. This allowed mathematical indices to be identified that were precisely correlated with the mini-mental test scores; in other words, we obtained new neuro-markers [brain markers] that may stand alone as indices of the subject’s cognitive status.”

 

Maimon adds: “We have actually succeeded in illustrating that music is indeed an effective tool for measuring brain activity. The brain activity and response times to tasks correlated to the subjects’ cerebral conditions (correlating to the mini-mental score assigned to them). More importantly, all those who underwent the experiment reported that, on the one hand, it challenged the brain, but on the other it was very pleasant to perform”.

 

The researchers conclude: “Our method enables the monitoring of cognitive capability and detection of cognitive decline already in the early stages, all by simple and accessible means, with a quick and easy test that can be conducted in any clinic. This method is of special importance today due to the increase in longevity and accelerated population growth, particularly among the elderly. Today, millions of people around the world already suffer or are liable to suffer soon from cognitive decline and its dire consequences, and their number will only increase in the coming decades. Our method could pave the way towards efficient cognitive monitoring of the general population, and thus detect cognitive decline in its early stages, when treatment and prevention of severe decline are possible. It is therefore expected to improve the quality of life of millions around the world.”

Scientific discovery may facilitate speedy, objective, and accurate diagnosis of the condition using saliva

Scientific discovery may facilitate speedy, objective, and accurate diagnosis of the condition using saliva.

A scientific breakthrough from the Tel Aviv and Haifa Universities may facilitate speedy, objective, and accurate diagnosis of people suffering from posttraumatic stress disorder, PTSD, using saliva samples, as well as developing microbiotic related medications (associated with the body’s microbial ecology).

 

The study was a joint effort by eminent scholars from various fields. It was led by Professor Illana Gozes and included Professor Noam Shomron, Dr. Shlomo Sragovich and Ph.D. student Guy Shapira, (all from TAU’s Sackler Faculty of Medicine and Sagol School of Neuroscience) as well as Prof. Zahava Solomon from TAU’s Gershon H. Gordon Faculty of Social Sciences, and Prof. Abraham Sagi-Schwartz and PhD student Ella Levert-Levitt from the Center for the Study of Child Development and the School of Psychological Sciences at Haifa University. The study was published in NATURE‘s prestigious MOLECULAR PSYCHIATRY magazine.

 

Diagnosing PTSD by Objective Criteria

The researchers tested a unique group of about 200 Israeli veteran soldiers (they all came from a larger cohort of subjects from a comprehensive four-decade-long study of veterans by Prof. Solomon) who had fought in the first Lebanon War in 1982. The test covered various psychological aspects, including sleep, appetite disorders, guilt, suicidal thoughts, social and spousal support, hostility, satisfaction with life, as well as issues of demographics, psychopathology, welfare, health, and education.

 

“We were surprised to discover that about a third of the PTSD subjects had never been diagnosed with post-trauma, so they never received any recognition from the Ministry of Defense and the official authorities.”

 

The researcher also collected saliva samples from them and comparing the results of the subjects’ microbial distribution to the psychological results and their responses to the welfare questionnaires, the researchers from the universities of Tel Aviv and Haifa found that people with PTSD and high psychopathological indications exhibit the same picture of bacteria in the saliva (a unique oral microbiotic signature).

According to the researchers, this study is significant in that for the first time, we might be able to diagnose post-trauma by objective criteria and not just behavioral ones.

One Third of Soldiers Were Undiagnosed

It is interesting to note here that the saliva bacteria of those exposed to air pollution showed a correlation to the picture with PTSD, while the number of years of education showed a protective influence and a reverse picture of the microbial ecology in the saliva. 

 

“To the best of our knowledge, this is the first depiction of a microbial signature in the saliva among veteran soldiers with PTSD,” says Prof. Illana Gozes. “We were surprised to discover that about a third of the PTSD subjects had never been diagnosed with post-trauma, so they never received any recognition from the Ministry of Defense and the official authorities.”

 

“To the best of our knowledge, this is the first depiction of a microbial signature in the saliva among veteran soldiers with PTSD,”

 

“It must be stressed that until now, post-trauma diagnosis has been based solely on psychological and psychiatric measures. Thanks to this study, it may be possible, in the future, to use objective molecular and biological characteristics to distinguish PSTD sufferers, taking into account environmental influences. We hope that this new discovery and the microbial signatures described in this study might promote easier diagnosis of post-traumatic veteran soldiers so they can receive appropriate treatment.”

The study was also supported by IDF’s Medical Corps Department of Health and Well-Being and Dr. Ariel Ben Yehuda, former chief of the above Department and currently, a Department Manager in the Mental Health Medical Center in Shalvata, Clallit Health Services. The study also involved collaboration with the Charité University Medicine in Berlin and its microbiology experts Dr. Markus M. Heimesaat and Professor Stefan Bereswill, as well as with the University of Hong Kong, which is studying the effects of air pollution, Professors Victor Li and Jacqueline Lam.

New Perspectives on Tackling Human Trafficking

Prof. Hila Shamir is among TAU scholars fighting modern slavery.

In light of the World Day against Trafficking in Persons on July 30, we caught up with Prof. Hila Shamir to discuss her trailblazing legal research aimed at combating human trafficking in Israel and around the globe. 

According to the latest estimates, over 40 million people are victims of modern slavery in which individuals perform labor or services under highly exploitative conditions. Their vulnerability to exploitation is often the result of poverty, exclusion or migratory status.  

While trafficking is generally thought of as the exploitation in the sex industry, Shamir is among scholars helping to expand the understanding of the phenomenon to include severe forms of labor market exploitation in other labor sectors. For example, this includes the exploitation of workers in industries such as domestic and care work, construction, agriculture, mining, and fishing who are forced to work in inhumane conditions. Such circumstances include working for long hours, in physically unsafe work environments with little to no pay, and with limitations on their liberties and freedom of movement.  

Top-Down Approach 

“While it is possible to effectively combat human trafficking, to do so requires a willingness to address structural elements, such as restrictive migration regimes and harmful labor market regulation,” says Shamir.  

 

She heads the TraffLab research group at the Buchmann Faculty of Law. Her interdisciplinary team includes students and researchers as well as lawyers from TAU’s Workers’ Rights Clinic, where she serves as the academic advisor. The Clinic supports Shamir’s research through the cases it represents in court. 

Shamir won a competitive grant from the EU’s European Research Council for TraffLab’s research. She was the first legal scholar in Israel to win the ERC Starting Grant for outstanding early-career researchers. The ERC also nominated her lab as a finalist for its 2022 Public Engagement with Research Award for its activity building bridges between research and policymaking. 

Prof. Hila Shamir. (Photo: Hadas Parush/Haaretz)

New Legal Tools 

Shamir’s research seeks to formulate new legal tools to fight human trafficking with labor-based strategies alongside traditional approaches focused on criminal law, border control, and human rights. These strategies target the underlying economic, social and legal structures of labor markets prone to severely exploitative practices.  

With her work, Shamir aims to transform the way trafficking is researched and, as a result, the way anti-trafficking policy is devised. 

While this is no simple feat, she remains optimistic: “There are examples around the world showing us that this can be done if we are willing to move beyond criminalization and expand anti-trafficking toolkit towards strengthening the bargaining power and improving the rights of the most vulnerable workers.”  

She explains that migrant and non-citizen workers are among those most vulnerable to labor trafficking, often due to their legal or social status and institutionalized corruption among employers. 

Impacting the National Debate 

In a significant project, Shamir’s team devised a comprehensive policy plan that proposes alternative recommendations to Israel’s current national plan on trafficking. Shamir recently presented the strategy suggestion to various Israeli government stakeholders and Knesset committees, and held a public roundtable about the plan with the UN Rapporteur on trafficking. The project also led her team to submit several branch-off policy papers over the past year to Israeli policymakers overseeing foreign workers’ rights and related topics. 

Going forward, Shamir is pushing full force ahead with her research as well as public and policy engagement on trafficking. This includes several recent and impending publications based on her research on Israel, modern slavery in global value chains, and bilateral labor agreements, which are among the types of structural frameworks that affect the recruitment practices and labor conditions that can lead to trafficking. 

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